Circulating fatty acid profiles in response to three levels of dietary omega-3 fatty acid supplementation in horses.

@article{King2008CirculatingFA,
  title={Circulating fatty acid profiles in response to three levels of dietary omega-3 fatty acid supplementation in horses.},
  author={S. S. King and Amer A. AbuGhazaleh and Stephen K. Webel and K. L. Jones},
  journal={Journal of animal science},
  year={2008},
  volume={86 5},
  pages={
          1114-23
        }
}
Fatty acids of the n-3 type confer health benefits to humans and other species. Their importance to equine physiology could include improved exercise tolerance, decreased inflammation, and improved reproductive function. The circulating fatty acid profile and the acquisition and washout of fatty acids in response to n-3 supplementation were determined for horses in the current study. A fatty acid supplement high in eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid was fed to deliver EPA… 

Figures and Tables from this paper

Effect of n-3 polyunsaturated fatty acids on markers of inflammation in young horses in training
TLDR
Diet did not affect serum CPII or CS-846 nor synovial white blood cell count, total protein, and specific gravity, but plasma eicosapentaenoic Acid and docosahexaenoic acid increased in response to supplementation.
Fatty acid profiles of the plasma and follicular fluid mares fed a combination of linseed and salmon oil.
TLDR
Data indicated a low to moderate relationship between the dietary linseed-based oil supplementation studied and circulating and follicular fluid polyunsaturated fatty acids contents in mares.
Dynamics of DHA and EPA supplementation: incorporation into equine plasma, synovial fluid, and surfactant glycerophosphocholines.
TLDR
DHA and EPA supplementation results in augmented storage pools of ω-3 essential fatty acids in SF and surfactant GPC, which has the potential to improve the ability of anti-inflammatory mechanisms to resolve inflammatory pathways in these critical compartments involved in arthritis and asthma.
Omega‐3 Fatty Acid Supplementation Provides an Additional Benefit to a Low‐Dust Diet in the Management of Horses with Chronic Lower Airway Inflammatory Disease
TLDR
Feeding horses with RAO and IAD a PUFA supplement containing 1.5–3 g DHA for 2 months provides an additional benefit to low‐dust diet.
Effect of dietary omega-3 fatty acid source on plasma and red blood cell membrane composition and immune function in yearling horses.
TLDR
Across treatments, the peak increase in skin thickness was observed 4 to 8 h after PHA injection, and fish oil had a greater impact on plasma and RBC n-3 FA content than did flaxseed, however, supplementing horses with both fish oil and flax Seed resulted in a more pronounced early inflammatory response to PHA injections as compared with nonsupplemented horses.
Dietary supplementation of conjugated linoleic acid in horses increases plasma conjugated linoleic acid and decreases plasma arachidonic acid but does not alter body fat.
TLDR
In an equine model, dietary CLA increases circulating concentrations of supplemented CLA isomers and decreases circulating C20:4, the major substrate of cyclooxygenase (COX) II inflammatory pathway.
Effects of two different dietary sources of long chain omega-3, highly unsaturated fatty acids on incorporation into the plasma, red blood cell, and skeletal muscle in horses.
TLDR
This is the first study to demonstrate that dietary fatty acid supplementation will affect muscle fatty acid composition in horses and incorporation of n-3 LCHUFA into blood and muscle depends directly on dietary supply of specific fatty acids.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 23 REFERENCES
Effects of dietary flaxseed oil supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation.
TLDR
In healthy horses supplemented with flaxseed oil, platelet aggregation was not altered, which may have been due to the limited biologic effect in healthy subjects or the inability of flax Seed Oil to induce the necessary biochemical effect of replacing n-6 fatty acids with n-3 types.
The effects of dietary N-3 and antioxidant supplementation on erythrocyte membrane fatty acid composition and fluidity in exercising horses.
TLDR
An enriched oral antioxidant supplementation induced changes in membrane composition, which modulated the decrease in EMF induced by exercise, and long chain n-3 fatty acid supplementation might therefore be beneficial.
Effects of altering dietary fatty acid composition on prostaglandin synthesis and fertility.
TLDR
The evidence reviewed shows that alteration of the concentration and ratio of n-6 and n-3 PUFAs in feeds can influence prostaglandin synthesis/metabolism in a number of mammalian systems, including cattle and other mammals.
Dietary (n-3) fatty acids from menhaden fish oil alter plasma fatty acids and leukotriene B synthesis in healthy horses.
TLDR
It is suggested that dietary polyunsaturated fatty acids modulate the leukotriene inflammatory response of horses and fish oil supplementation may have value in treatment of equine inflammatory diseases.
Distribution, interconversion, and dose response of n-3 fatty acids in humans.
TLDR
It is concluded that the most predictable way to increase a specific long-chain n-3 fatty acid in plasma, tissues, or human milk is to supplement with the fatty acid of interest.
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
  • A. Simopoulos
  • Medicine, Biology
    Journal of the American College of Nutrition
  • 2002
TLDR
Animal experiments and clinical intervention studies indicate that omega-3 fatty acids have anti-inflammatory properties and, therefore, might be useful in the management of inflammatory and autoimmune diseases.
LONG CHAIN FATTY ACIDS IN HEALTH AND NUTRITION
TLDR
Recommendations by many academic and governmental bodies propose that daily intakes on long chain omega-3 fatty acids be increased as a step in reducing certain chronic diseases.
Effects of the omega-3 fatty acid, alpha-linolenic acid, on lipopolysaccharide-challenged synovial explants from horses.
TLDR
Investigation of alpha-linolenic acid as an anti-inflammatory medication for equine synovitis is warranted and results suggest that investigation of omega-3 polyunsaturated fatty acid as a anti- inflammation medication is warranted.
Incorporation of n−3 fatty acids of fish oil into tissue and serum lipids of ruminants
TLDR
In the total PL of muscle, the incorporated 20∶5 and 22∶6 substituted primarily for oleic and linoleic acid, and there was no consistent change in the porportion of arachidonic (20∶4) acid.
Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk.
TLDR
Solin supplementation in a lactation diet is a superior method to increase CLA levels in milk fat than feeding fresh forage alone.
...
1
2
3
...