Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model.

@article{Channell2012CirculatingFI,
  title={Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model.},
  author={Meghan M. Channell and Michael L. Paffett and Robert B. Devlin and Michael C. Madden and M. Campen},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={127 1},
  pages={179-86}
}
The vascular toxicity of inhaled agents may be caused by soluble factors that are released into the systemic circulation. To confirm this in a straightforward manner, we obtained plasma from healthy human volunteers before and after exposure to diesel exhaust (DE) and nitrogen dioxide (NO(2)). Plasma samples were obtained from human volunteers exposed to 100 μg/m(3) DE or filtered air for 2 h. A second cohort was exposed to 500 ppb NO(2) or filtered air in an identical protocol. Primary human… CONTINUE READING
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