Circulating endotoxin during initial antibiotic treatment of severe gram-negative bacteremic infections.

@article{Maury1998CirculatingED,
  title={Circulating endotoxin during initial antibiotic treatment of severe gram-negative bacteremic infections.},
  author={Eric Maury and Vanda Barakett and Herv{\'e} Blanchard and Cathy Guitton and Catherine Fitting and Thierry Vassal and Pierre Chauvin and Bertrand Guidet and Georges Offenstadt},
  journal={The Journal of infectious diseases},
  year={1998},
  volume={178 1},
  pages={
          270-3
        }
}
The impact of antibiotics on total endotoxemia and circulating tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 in 18 patients with severe bacteremic sepsis or septic shock due to gram-negative species was investigated. Endotoxemia, TNF-alpha, IL-6, and IL-8 were assayed before (H0) and 1 h (H1) and 4 h (H4) after the first antibiotic infusion. Endotoxemia decreased from H0 (median, 0.4 EU/mL; interquartile interval, 0.09-1.23) to H1 (median, 0.19 EU/mL; interquartile interval, 0… CONTINUE READING

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