Circulating endotoxin, tumour necrosis factor-alpha, and their natural antagonists in the pathophysiology of acute pancreatitis.

@article{Beaux1996CirculatingET,
  title={Circulating endotoxin, tumour necrosis factor-alpha, and their natural antagonists in the pathophysiology of acute pancreatitis.},
  author={Andrew C de Beaux and K. C. Fearon},
  journal={Scandinavian journal of gastroenterology. Supplement},
  year={1996},
  volume={219},
  pages={43-6}
}
Inflammatory mediators, such as endotoxin and tumour necrosis factor-alpha (TNF-alpha) have been implicated in the pathogenesis of acute pancreatitis. However, serum levels of these mediators in patients with acute pancreatitis are often not detectable on hospital admission. In contrast, their circulating antagonists (antiendotoxin antibodies and soluble TNF-alpha receptors) are detectable in all patients. With increasing severity of disease, patients are more likely to manifest a fall in… CONTINUE READING