Circulating endothelial cells and vascular cell adhesion molecule-1 correlates with severity of regurgitation lesion and heart failure in rheumatic heart disease

@article{Sasmeita2015CirculatingEC,
  title={Circulating endothelial cells and vascular cell adhesion molecule-1 correlates with severity of regurgitation lesion and heart failure in rheumatic heart disease},
  author={Wulan Sasmeita and Renny Suwarniaty and Loeki Enggar Fitri and Mohammad Saifur Rohman and Siti Lintang Kawuryan},
  journal={Journal of Experimental and Integrative Medicine},
  year={2015},
  volume={5},
  pages={157-164}
}
Objective: This study aims to determine the correlation of vascular cell adhesion molecule-1 (VCAM-1) and circulating endothelial cells (CEC) with cardiac valves lesion severity and heart failure (HF) in rheumatic heart disease (RHD). Methods: A cross-sectional observational study using human peripheral blood samples of 36 children aged 6 to14 years old, divided into two groups: 18 RHD patients and 18 healthy controls group. The expression of CECs and VCAM-1 on CECs was investigated by using… 
View via Publisher
ejmanager.com

Figures and Tables from this paper

References

SHOWING 1-10 OF 39 REFERENCES

Circulating Endothelial Cells in Patients with Heart Failure and Left Ventricular Dysfunction

CEC levels are associated with the acute phase of heart failure and could be used as a marker of the worsening in heart failure, providing further support for CEC as markers of endothelial damage.

Vascular Cell Adhesion Molecule-1 as a Prognostic Marker in Patients with End-stage Heart Failure

The findings indicate that measurement of sVCAM-1 may have the potential to play an important role for risk assessment in patients with ESHF.

Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement.

Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor.

Heart Valve Lesions Due to the Formation of a Beta-Hemolytic Streptococ Role of Adhesion Molecules

The fact that increases in serum VCAM-1 and CD-11b only occurred in patients with rheumatic valvular disease in this study suggests that inflammation in Patients with the same hemodynamic disorder is higher in rhematic valVular disease than in the ones with non-rheumatic VAL disease.

[Concentration and significance of s-ICAM-1, s-VCAM-1, and vWF in the plasma of patients with rheumatic heart disease].

The concentrations of s-ICam-1, s-VCAM-1 and vWF levels were significantly elevated in patients with static rheumatic fever, which might be one of the pathogenic mechanisms of valvular damage, endothelial dysfunction, and myocardial damage in rhematic heart disease.

Circulating Endothelial Cells And Cardiovascular Risk In Systemic Lupus Erythematosus

Increased number of CECs in SLE patients may represent one of the first specific cellular markers to provide a direct link with the pathophysiology of cardiovascular disease (CVD) and may predict patients at increased risk of CVD complications, lupus nephritis or vasculitic skin affection.

Prediction of Residual Valvular Lesions in Rheumatic Heart Disease: Role of Adhesion Molecules

Levels of serum adhesion molecules could predict residual valvular lesions in RHD patients and are recommended to be measured in all cases of ARF carditis.

Circulating endothelial cells in cardiovascular disease.

Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular lesions.