Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer

  title={Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer},
  author={Gregor F{\"u}rstenberger and Roger von Moos and Rudolf Lucas and Beat J K Thuerlimann and H. I. Senn and Juerg Hamacher and E-M Boneberg},
  journal={British Journal of Cancer},
  pages={524 - 531}
Circulating endothelial cells (CECs) as well as bone-marrow-derived endothelial precursor cells (EPC) play an important role in neovascularisation and tumour growth. To study the impact of neoadjuvant chemotherapy on the amounts of CEC and their precursor cells, mature CEC and their progenitors were quantified by flow cytometry in peripheral blood of breast cancer patients during anthracycline and/or taxane based neoadjuvant chemotherapy and subsequent surgery in comparison to age-matched… CONTINUE READING


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