Circulating cytokines and chemokines associated with plasma leakage and hepatic dysfunction in Brazilian children with dengue fever.

@article{Ferreira2015CirculatingCA,
  title={Circulating cytokines and chemokines associated with plasma leakage and hepatic dysfunction in Brazilian children with dengue fever.},
  author={Ralph Antonio Xavier Ferreira and Solange Artimos de Oliveira and Mariana Gandini and Laura da Cunha Ferreira and G. V. V. Corr{\^e}a and Fernanda Mattos Abiraude and Mariana Mancebo Reid and Oswaldo G. Cruz and Claire Fernandes Kubelka},
  journal={Acta tropica},
  year={2015},
  volume={149},
  pages={138-47}
}
Dengue fever is usually a benign acute viral infection transmitted by arthropods but may evolve to severe clinical manifestations such as coagulation and/or hemodynamic disorders, caused mainly by an increase of vascular permeability. Deregulated circulating immunological factors have been associated with severity. In Brazil severe cases appeared in children only recently and we evaluated the profile of cytokine/chemokine kinetics in 134 hospitalized young patients during the epidemic in Rio de… CONTINUE READING