Circulating cytokines: the tip of the iceberg?

  title={Circulating cytokines: the tip of the iceberg?},
  author={J M Cavaillon and Christine Munoz and Catherine Fitting and Benoit Y Misset and Jean M. Carlet},
  journal={Circulatory shock},
  volume={38 2},
Circulating cytokines, particularly TNF alpha, IL-1, IL-6 and IL-8, can be detected during severe infections consecutively to an exacerbate release by activated cells. The presence or absence of cytokines within biological fluids reflects a rather complex balance between enhancing and inhibitory signals acting on producer cells, between production and catabolism, and between their binding to the target cells and the modulation of their receptors on the cell surface. Furthermore, their presence… CONTINUE READING

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