Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.

@article{Osanai2003CirculatingCF,
  title={Circulating coupling factor 6 in human hypertension: role of reactive oxygen species.},
  author={Tomohiro Osanai and Satoko Sasaki and Takaatsu Kamada and Naoto Fujiwara and Takao Nakano and Hirofumi Tomita and Toshiro Matsunaga and Koji Magota and Ken Okumura},
  journal={Journal of hypertension},
  year={2003},
  volume={21 12},
  pages={
          2323-8
        }
}
OBJECTIVE Coupling factor 6 is an endogenous inhibitor of prostacyclin synthesis and might function as an endogenous vasoconstrictor in the fashion of a circulating hormone in rats. We investigated the role of coupling factor 6 in human hypertension. METHODS AND RESULTS The patients with essential hypertension (EH) (n = 30) received a series of normal salt diet (12 g salt/day) for 3 days, low salt diet (2 g salt/day) for 7 days, and high salt diet (20-23 g salt/day) for 7 days. Normotensive… CONTINUE READING

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