Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.

@article{Gou2013CirculatingCA,
  title={Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.},
  author={Shen-ju Gou and Jun Yuan and Min Chen and Feng Yu and Ming-Hui Zhao},
  journal={Kidney international},
  year={2013},
  volume={83 1},
  pages={129-37}
}
Studies in animal models suggest that complement activation is crucial in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). Here we investigate the circulating complement activation profile of 66 patients with active stage AAV compared to that of 54 patients with AAV in remission. Plasma levels of C3a, C5a, soluble C5b-9, and Bb, all determined by enzyme-linked immunosorbent assay, were significantly higher in active stage than in remission of AAV, while… CONTINUE READING
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