Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: possible pathway for fibronectin deposition and turnover in the rat liver.

@article{Rotundo1998CirculatingCF,
  title={Circulating cellular fibronectin may be a natural ligand for the hepatic asialoglycoprotein receptor: possible pathway for fibronectin deposition and turnover in the rat liver.},
  author={Robert F Rotundo and Raquel Rebres and Paula J. McKeown-Longo and Frank A. Blumenstock and Thomas M. Saba},
  journal={Hepatology},
  year={1998},
  volume={28 2},
  pages={475-85}
}
It has been postulated that the in vivo removal of many plasma glycoproteins after desialylation is mediated by their interaction with a specific endocytic receptor on hepatocytes called the asialoglycoprotein receptor (ASGP-R), which is known to have a high affinity for specific carbohydrate residues, such as galactose. However, this mechanism has never been proven in vivo, nor has a naturally occurring ligand for the ASGP-R been identified. We investigated the influence of the terminal… CONTINUE READING
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