Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model.

@article{Kumagai2008CirculatingCW,
  title={Circulating cells with osteogenic potential are physiologically mobilized into the fracture healing site in the parabiotic mice model.},
  author={Ken Kumagai and Amit Vasanji and Judith A. Drazba and Robert S. Butler and George F. Muschler},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2008},
  volume={26 2},
  pages={165-75}
}
Based on the accumulating evidence of osteogenic cells present in the systemic circulation, we hypothesized that circulating osteogenic connective tissue progenitors (CTPs) home to fracture site and contribute to skeletal repair. Parabiotic animals were formed by surgically conjoining transgenic mice constitutively expressing green fluorescent protein (GFP) in no erythroid tissue and syngeneic wild-type mice. After 3 weeks parabionts, equilibrium in blood chimerism between partners was… CONTINUE READING
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