Circulating cell free DNA: a marker to predict the therapeutic response for biological DMARDs in rheumatoid arthritis.

@article{Hashimoto2017CirculatingCF,
  title={Circulating cell free DNA: a marker to predict the therapeutic response for biological DMARDs in rheumatoid arthritis.},
  author={Teppei Hashimoto and Kohsuke Yoshida and Naonori Hashimoto and Ayako Nakai and Kenta Kaneshiro and Kohjin Suzuki and Yoshiko Kawasaki and Nao Shibanuma and Akira Hashiramoto},
  journal={International journal of rheumatic diseases},
  year={2017},
  volume={20 6},
  pages={722-730}
}
AIM To evaluate the correlation between circulating cell-free DNA (ccfDNA) in plasma and clinical disease activities in patients with rheumatoid arthritis (RA). METHOD The study group included 30 patients with RA who started biological disease-modifying anti-rheumatic drugs (DMARDs) therapy. The concentration of ccfDNA in plasma was measured by quantitative real-time polymerase chain reaction at baseline to 24 weeks in every 4-week period from 30 patients and 21 healthy individuals. We also… CONTINUE READING

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