Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.

@article{Yu2013CirculatingBT,
  title={Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition.},
  author={Min Yu and Aditya Bardia and Ben S. Wittner and Shannon L. Stott and Malgorzata E. Smas and David T. Ting and Steven Jay Isakoff and Jordan C Ciciliano and Marissa N Wells and Ajay M. Shah and Kyle F. Concannon and Maria Christine Donaldson and Lecia V Sequist and Elena F. Brachtel and Dennis C. Sgroi and Jos{\'e} Baselga and Sridhar Ramaswamy and Mehmet Toner and Daniel A. Haber and S. Maheswaran},
  journal={Science},
  year={2013},
  volume={339 6119},
  pages={580-4}
}
Epithelial-mesenchymal transition (EMT) of adherent epithelial cells to a migratory mesenchymal state has been implicated in tumor metastasis in preclinical models. To investigate its role in human cancer, we characterized EMT in circulating tumor cells (CTCs) from breast cancer patients. Rare primary tumor cells simultaneously expressed mesenchymal and epithelial markers, but mesenchymal cells were highly enriched in CTCs. Serial CTC monitoring in 11 patients suggested an association of… CONTINUE READING
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