Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.

@article{Wood2013CirculatingBE,
  title={Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.},
  author={Katherine C Wood and Miriam M Cortese-Krott and Jason C Kovacic and Audrey Noguchi and Virginia B. Liu and Xiaojing Wang and Nalini Raghavachari and Manfred Dr Ing Boehm and Gregory J. Kato and Malte Kelm and Mark T Gladwin},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 8},
  pages={
          1861-71
        }
}
OBJECTIVE Mice genetically deficient in endothelial nitric oxide synthase (eNOS(-/-)) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. Although the current paradigm holds that this bioactivity derives specifically from the expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO… CONTINUE READING

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