Circulating biomarkers for discrimination between aseptic joint failure, low-grade infection, and high-grade septic failure.

@article{Ettinger2015CirculatingBF,
  title={Circulating biomarkers for discrimination between aseptic joint failure, low-grade infection, and high-grade septic failure.},
  author={Max Ettinger and Tilman Calliess and Jan T Kielstein and Jasmin Sibai and Thomas Br{\"u}ckner and Ralf Lichtinghagen and Henning Windhagen and Alexander Lukasz},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2015},
  volume={61 3},
  pages={332-41}
}
BACKGROUND Late-onset chronic (low-grade) periprosthetic joint infections are often accompanied by unspecific symptoms, false-negative cultures or nonspecific low values of serum biomarkers. This may lead to the unintended implantation of a revision prosthesis into an infected surgical site with the risk of short-term failure developing again. Conversely, false diagnosis of joint infection may result in multistage revision procedures, which expose the patient to unnecessary surgical procedures… CONTINUE READING
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