Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis.

@article{Stevens1992CirculatingAT,
  title={Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis.},
  author={Tamara J. Stevens and Vivienne R Winrow and David R. Blake and David S Rampton},
  journal={Clinical and experimental immunology},
  year={1992},
  volume={90 2},
  pages={271-4}
}
Heat-shock proteins (HSPs) are highly conserved immunogenic intracellular molecules that are induced by inflammatory mediators and may induce autoimmune phenomena in vivo. We have recently demonstrated the increased expression of HSP-60 in the colonocytes of patients with ulcerative colitis. To study further the role of HSP-60 in inflammatory bowel disease, we have now measured antibodies to recombinant mycobacterial HSP-65 (a member of the HSP-60 family) in patients with Crohn's disease… CONTINUE READING