Circulating antibodies and macrophages as modulators of adenovirus pharmacology.

  title={Circulating antibodies and macrophages as modulators of adenovirus pharmacology.},
  author={Reeti Khare and Matthew L. Hillestad and Zhili Xu and Andrew P Byrnes and Michael Anthony Barry},
  journal={Journal of virology},
  volume={87 7},
Adenovirus serotype 5 (Ad5) naturally infects the liver after intravenous injection, making it a candidate for hepatocyte-directed gene transfer. While Ad5 can be efficient, most of the dose is destroyed by liver Kupffer cells before it can reach hepatocytes. In contrast, Ad5 bearing the hexon from Ad6 (Ad5/6) evades Kupffer cells. While Ad5/6 dramatically increases hepatocyte transduction in BALB/c mice, it has surprisingly little effect on C57BL/6 mice. To determine the source of this strain… CONTINUE READING

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