Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia

@article{Schliemann2007CirculatingAI,
  title={Circulating angiopoietin-2 is a strong prognostic factor in acute myeloid leukemia},
  author={Christoph Schliemann and Ralf Bieker and Nils H. Thoennissen and Joachim Ger\ss and R{\"u}ediger Liersch and T Woodrow Kessler and T. B{\"u}chner and Wolfgang E. Berdel and R. M. Mesters},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1901-1906}
}
Angiogenesis plays an important role in solid tumors and hematologic malignancies. The angiopoietins act as essential regulators in this process. We investigated the impact of circulating angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2) and soluble Tie2 (sTie2) on overall survival in patients with acute myeloid leukemia (AML). Ang-1, Ang-2 and sTie2 were measured in plasma samples from 68 AML patients and 11 controls using enzyme-linked immunosorbent assay. Circulating levels of Ang-2 and sTie2… CONTINUE READING

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