Circulating angiogenic factors and abnormal uterine artery Doppler velocimetry in the second trimester.

@article{Muller2006CirculatingAF,
  title={Circulating angiogenic factors and abnormal uterine artery Doppler velocimetry in the second trimester.},
  author={Peter R Muller and Andra H. James and Amy P. Murtha and Bryan A Yonish and Margaret G. Jamison and Gustaaf Dekker},
  journal={Hypertension in pregnancy},
  year={2006},
  volume={25 3},
  pages={183-92}
}
OBJECTIVE Circulating angiogenic growth factors (such as vascular endothelial growth factor [VEGF] and placental growth factor [PlGF]) and their interaction may be associated with vascular remodeling of spiral arteries in normal pregnancy. Soluble Flt-1, an antagonist of both VEGF and PlGF, has been shown to be increased, while PlGF is decreased in women prior to the onset of preeclampsia. The purpose of this study was to compare maternal soluble Flt-1 and PlGF levels in the second trimester… CONTINUE READING