Circulating angiogenic cytokines in patients with advanced non-small cell lung cancer: correlation with treatment response and survival.

@article{Dudek2005CirculatingAC,
  title={Circulating angiogenic cytokines in patients with advanced non-small cell lung cancer: correlation with treatment response and survival.},
  author={Arkadiusz Z. Dudek and Hemchandra Mahaseth},
  journal={Cancer investigation},
  year={2005},
  volume={23 3},
  pages={193-200}
}
Tumor angiogenesis is stimulated by a pro-angiogenic shift in both inducers and inhibitors of endothelial growth. To study this shift, we measured serum and plasma levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), endostatin, and thrombospondin 1 (TSP1) in 21 advanced non-small cell lung cancer (NSCLC) patients and 46 healthy control subjects. In addition, we assessed the relevance of these levels to disease outcome. Cytokine levels were prospectively… CONTINUE READING

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