Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration.

@article{Sheron1993CirculatingAT,
  title={Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration.},
  author={Nick Sheron and George Gwynne Bird and John Koskinas and Bernard Portmann and Miroslav Ceska and Ivan Lindley and Roger Williams},
  journal={Hepatology},
  year={1993},
  volume={18 1},
  pages={41-6}
}
Acute alcoholic hepatitis is characterized by a unique degree of liver neutrophil infiltration, often accompanied by marked peripheral neutrophilia in the absence of demonstrable bacterial or fungal infection. In this study we assayed plasma and tissue levels of a potent neutrophil activator and chemotaxin, interleukin-8, in patients with a spectrum of alcoholic liver diseases and in normal and diseased control subjects. Levels of circulating interleukin-8 were undetectable in normal subjects… CONTINUE READING

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