Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes.

@article{Hober2002CirculatingAC,
  title={Circulating and cell-bound antibodies increase coxsackievirus B4-induced production of IFN-alpha by peripheral blood mononuclear cells from patients with type 1 diabetes.},
  author={Didier Hober and Wassim Chehadeh and Jacques Weill and Christine Hober and M. C. Vantyghem and Pascale Gronnier and Pierre Wattr{\'e}},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 9},
  pages={
          2169-76
        }
}
Increased levels of IFN-alpha have been found in patients with type 1 diabetes who have detectable levels of coxsackievirus B4 (CVB4) RNA in their blood. The IFN-alpha-inducing activity of CVB4 in vitro is weak but can be enhanced by human IgGs. Therefore, it was investigated in vitro whether a preferential IFN-alpha response of peripheral blood mononuclear cells (PBMCs) to CVB4 exists in patients with type 1 diabetes (n=56) compared with healthy subjects (n=20) and whether antibodies play a… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 18 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Increased level of interferon-α in blood of patients with insulin-dependent diabetes mellitus : relationship with coxsackievirus B infection

D. Hober
  • Journal of Infectious Diseases
  • 2000

Fc receptor biology.

  • Annual review of immunology
  • 1997
VIEW 2 EXCERPTS

Similar Papers

Loading similar papers…