Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.

@article{Fldes2003CirculatingAC,
  title={Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.},
  author={G{\'a}bor F{\"o}ldes and Ferenc Horkay and Istv{\'a}n Szokodi and Olli Vuolteenaho and Mika Ilves and Ken A. Lindstedt and Mikko I M{\"a}yr{\"a}np{\"a}{\"a} and Bal{\'a}zs S{\'a}rm{\'a}n and Leila Seres and R{\'e}ka Skoumal and Zolt{\'a}n Lak{\'o}-Fut{\'o} and Rudolf deCh{\^a}tel and Heikki Ruskoaho and Mikl{\'o}s T{\'o}th},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={308 3},
  pages={480-5}
}
The orphan receptor APJ and its recently identified endogenous ligand, apelin, are expressed in the heart. However, their importance in the human cardiovascular system is not known. This study shows that apelin-like immunoreactivity is abundantly present in healthy human heart and plasma. Gel filtration HPLC analysis revealed that atrial and plasma levels of high molecular weight apelin, possibly proapelin, were markedly higher than those of mature apelin-36 itself. As assessed by quantitative… CONTINUE READING
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