Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man

@article{Fitzgerald1980CirculatingAA,
  title={Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man},
  author={G. A. Fitzgerald and Peter John Barnes and Carlene A. Hamilton and Colin T. Dollery},
  journal={European Journal of Clinical Investigation},
  year={1980},
  volume={10}
}
Abstract. Six normotensive volunteers were infused with L‐adrenaline at 001, 003, 005, 0075 and 010 μg/kg‐1 min‐1, each increment lasted 10 min. Plasma adrenaline rose from 0–27 to 4–61 nmol/1, and there were dose‐related increases in plasma renin activity, blood glucose, plasma cyclic AMP and plasma free fatty acids, but not in plasma noradrenaline and cyclic GMP. Levels of circulating adrenaline previously noted in essential hypertensives had minimal cardiovascular effects. The secretion rate… 
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It is concluded that there is no significant circadian change in adrenergic responses in asthma and that adrenoreceptor dysfunction is not important in the pathogenesis of nocturnal asthma.
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