Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization.

@article{Zhu2004CirculatingAL,
  title={Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization.},
  author={Min Zhu and Junnosuke Miura and Lucy X. Lu and Michel Bernier and Rafael Decabo and Mark A. Lane and George S. Roth and Donald K. Ingram},
  journal={Experimental gerontology},
  year={2004},
  volume={39 7},
  pages={1049-59}
}
Caloric restriction (CR) has a well-known insulin sensitizing effect in vivo. Although this effect has been confirmed in rodents and primates for many years, its precise molecular mechanisms remain unknown. Here we show a significant increase in plasma adiponectin and a decrease in blood glucose, plasma triglyceride and insulin levels in rats maintained on CR diet for 2, 10, 15, and 20 months. Long-term CR rats exhibited significantly higher insulin-stimulated insulin receptor tyrosine… CONTINUE READING
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