Circulating Very-Long-Chain SFA Concentrations Are Inversely Associated with Incident Type 2 Diabetes in US Men and Women.

  title={Circulating Very-Long-Chain SFA Concentrations Are Inversely Associated with Incident Type 2 Diabetes in US Men and Women.},
  author={Andres V Ardisson Korat and Vasanti Malik and Jeremy D. Furtado and Frank M. Sacks and Bernard A Rosner and Kathryn M. Rexrode and Walter C. Willett and Dariush Mozaffarian and Frank B. Hu and Qi Sun},
  journal={The Journal of nutrition},
BACKGROUND Very-long-chain SFAs (VLCSFAs), such as arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0), have demonstrated inverse associations with cardiometabolic conditions, although more evidence is needed to characterize their relation with risk of type 2 diabetes (T2D). In addition, little is known regarding their potential dietary and lifestyle predictors. OBJECTIVE We aimed to examine the association of plasma and erythrocyte concentrations of VLCSFAs with incident… Expand
Assessment of Plasma Phospholipid Very-Long-Chain Saturated Fatty Acid Levels and Healthy Aging.
Findings suggest that higher levels of circulating behenic acid and lignoceric acid are associated with lower risk of unhealthy aging events, highlighting the need to explore determinants of circulating VLSFAs for potential novel efforts to promote healthy aging. Expand
Plasma Free Fatty Acids and Metabolic Effect in Type 2 Diabetes, an Ancillary Study from a Randomized Clinical Trial
The results suggest that the intervention was successful and that participants were likely compliant, which supports the validity of the main trial. Expand
Biomarkers of fatty acids and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies
This study quantifies and generates comprehensive evidence on the associations of different fatty acids (FAs) with the risk of type 2 diabetes mellitus and finds a negative correlation between odd-chain saturated FAs, trans-FAs, total n-6, Δ-5-desaturase activities and risk of T2DM. Expand
Associations of Dairy Intake with Circulating Biomarkers of Inflammation, Insulin Response, and Dyslipidemia among Postmenopausal Women.
Higher dairy intake, except butter, was associated with a favorable profile of lipids, insulin response, and inflammatory biomarkers, regardless of fat content, yet, specific dairy foods might influence these markers uniquely. Expand
Plasma leptin level mirrors metabolome alterations in young adults
The leptin level was found to have a significant association with a substantial number of metabolites in women and men, while metabolites involved in amino acid metabolism were correlated to leptin in men. Expand
Effects of an Omega-3 and Vitamin D Supplement on Fatty Acids and Vitamin D Serum Levels in Double-Blinded, Randomized, Controlled Trials in Healthy and Crohn’s Disease Populations
The nutrient supplement increased serum levels of key N-3 PUFAs and vitamin D in both populations, showing the preparation was readily bioavailable. Expand
Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis and proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for patients. Expand


Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.
Results from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20: 0, 22:0, and 24:0 are each associated with a lower risk of diabetes. Expand
Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women
In US men and women, plasma VLCSFAs were independently associated with favorable profiles of blood lipids and other cardiovascular disease risk markers and a lower risk of CHD. Expand
Plasma phospholipid very-long-chain saturated fatty acids and incident diabetes in older adults: the Cardiovascular Health Study.
It is suggested that circulating VLSFAs are associated with a lower risk of diabetes, and these associations may be mediated by lower triglycerides and palmitic acid. Expand
Erythrocyte membrane phospholipid fatty acids, desaturase activity, and dietary fatty acids in relation to risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study.
The FA profile of erythrocyte membrane phospholipids and activity of desaturase enzymes are strongly linked to the incidence of type 2 diabetes. Expand
Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies.
Findings suggest that linoleic acid has long-term benefits for the prevention of type 2 diabetes and that arachidonic acid is not harmful. Expand
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
Different individual plasma phospholipid SFAs were associated with incident type 2 diabetes in opposite directions, which suggests that SFAs are not homogeneous in their effects. Expand
Fasting Whole Blood Fatty Acid Profile and Risk of Type 2 Diabetes in Adults: A Nested Case Control Study
It is suggested that higher fasting whole blood concentrations of omega-6 polyunsaturated fatty acids (n-6PUFA) (ARA and DGLA) as well as omega-3 polyuns saturated fatty acid (ALA, EPA, and DHA) are associated with an increased risk of diabetes, whereas increased fasting wholeBlood concentrations of lignoceric acid is inversely associated with diabetes risk. Expand
Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study
Results from this prospective cohort study of older adults demonstrate divergent associations of circulating 16:0 versus longer‐chain saturated fatty acids with incident AF, highlighting the need to investigate both determinants of these levels and potential pathways of the observed differential risk. Expand
Ceramide stearic to palmitic acid ratio predicts incident diabetes
The ceramide ratio is an independent predictive biomarker for incident diabetes, and may be modulated by lifestyle intervention. Expand
Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest.
Higher levels of erythrocyte very long-chain saturated fatty acids (VLSFA) were associated with lower risk of SCA, and support the need for investigation of biologic effects of circulating VLSFA and their determinants. Expand