Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients.

@article{Vliet2005CirculatingVN,
  title={Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients.},
  author={Hans J. J. van der Vliet and Johan W. Molling and Brigitta Mary E von Blomberg and Wendy K{\"o}lgen and Anita G. M. Stam and Tanja D. de Gruijl and Chris Jacob Johan Mulder and Harry L. A. Janssen and Nobusuke Nishi and Alfons J. M. van den Eertwegh and Rik J. Scheper and Carin M. J. van Nieuwkerk},
  journal={Clinical immunology},
  year={2005},
  volume={114 2},
  pages={183-9}
}
CD1d-restricted natural killer T (NKT) cells are involved in the regulation of various immune responses, and have been shown to inhibit viral replication in animal hepatitis models when activated by the glycolipid alpha-galactosylceramide (alpha-GalCer, KRN7000). Previous studies have indicated that alpha-GalCer-induced activation of the immune system requires both CD1d expression by antigen-presenting cells as well as (normal) numbers of NKT cells. Discrepancies exist over circulating numbers… CONTINUE READING
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