Circulating Tumor Necrosis Factor-α Levels and Lipid Abnormalities in Patients with Cystic Fibrosis

@article{Lvy1993CirculatingTN,
  title={Circulating Tumor Necrosis Factor-α Levels and Lipid Abnormalities in Patients with Cystic Fibrosis},
  author={{\'E}mile L{\'e}vy and Covadonga Gurbindo and Florence Lacaille and Khazal Paradis and Louise Thibault and Ernest G Seidman},
  journal={Pediatric Research},
  year={1993},
  volume={34},
  pages={162-165}
}
ABSTRACT: Hyperlipidemia is prominent among the disturbances in intermediary metabolism that occur subsequent to infections by microorganisms. The response to such infections is known to involve several cell types and is mediated by cytokines. We hypothesized that metabolic lipid disturbances seen during infection in cystic fibrosis (CF) patients may partly be the result of excessive tumor necrosis factor-α (TNF-α), a proinflammatory cytokine known to cause a large spectrum of pathophysiologic… CONTINUE READING
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