Circulating Tumor Necrosis Factor-α Levels and Lipid Abnormalities in Patients with Cystic Fibrosis

  title={Circulating Tumor Necrosis Factor-α Levels and Lipid Abnormalities in Patients with Cystic Fibrosis},
  author={{\'E}mile L{\'e}vy and Covadonga Gurbindo and Florence Lacaille and Khazal Paradis and Louise Thibault and Ernest G Seidman},
  journal={Pediatric Research},
ABSTRACT: Hyperlipidemia is prominent among the disturbances in intermediary metabolism that occur subsequent to infections by microorganisms. The response to such infections is known to involve several cell types and is mediated by cytokines. We hypothesized that metabolic lipid disturbances seen during infection in cystic fibrosis (CF) patients may partly be the result of excessive tumor necrosis factor-α (TNF-α), a proinflammatory cytokine known to cause a large spectrum of pathophysiologic… CONTINUE READING
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Human VLDL and chylomicrons can protect against endotoxin-induced death in mice

  • HW Hanis, C Grunfeld, KR Feingold, Rapp
  • J Clin Invest
  • 1990

Tumor necrosis factor: immunologic. antitumor, metabolic and cardiovascular activities

  • C Gmnfeld, MA Palladino
  • Adv Intern Med
  • 1990

Cystic fibrosis

  • MJ BoatT.Welsh, Beaud
  • Scriver CR. Beaudet AL. Sly WS, Valle D (eds) The…
  • 1989

Dayer JM I 989 Relation between tumor necrosis factor - alpha and granulocyte elastase - ~ r l - proteinase inhibitor complexes in the plasma of patients with cystic fibrosis

  • KR Feingold, M Soued, MK Jerio, AH Moser, CA Dinarello, C Grunfeld
  • Am Rev Respir Dis
  • 1989

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