Circulating Skeletal Stem Cells

@article{Kuznetsov2001CirculatingSS,
  title={Circulating Skeletal Stem Cells},
  author={Sergei Kuznetsov and Mahesh H. Mankani and Stan Gronthos and Kazuhito Satomura and P. Rizzo M. Bianco and Pamela Robey},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={153},
  pages={1133 - 1140}
}
We report the isolation of adherent, clonogenic, fibroblast-like cells with osteogenic and adipogenic potential from the blood of four mammalian species. These cells phenotypically resemble but are distinguishable from skeletal stem cells found in bone marrow (stromal stem cells, "mesenchymal stem cells"). The osteogenic potential of the blood-borne cells was proven by an in vivo transplantation assay in which either polyclonal or single colony-derived strains were transplanted into the… CONTINUE READING

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