Circulating Sclerostin and Dickkopf-1 (DKK1) in Predialysis Chronic Kidney Disease (CKD): Relationship with Bone Density and Arterial Stiffness

@article{Thambiah2012CirculatingSA,
  title={Circulating Sclerostin and Dickkopf-1 (DKK1) in Predialysis Chronic Kidney Disease (CKD): Relationship with Bone Density and Arterial Stiffness},
  author={Seethaletchumy Thambiah and Rakshita Roplekar and P. Manghat and Ignac Fogelman and W. D. Fraser and David J. A. Goldsmith and Geeta N Hampson},
  journal={Calcified Tissue International},
  year={2012},
  volume={90},
  pages={473-480}
}
Abnormalities of bone metabolism and increased vascular calcification are common in chronic kidney disease (CKD) and important causes of morbidity and mortality. The Wnt signaling pathway may play a role in the bone and vascular disturbances seen in CKD, termed collectively “CKD–MBD.” The aim of the study was to investigate the possible association of circulating concentrations of the secreted Wnt signaling inhibitors DKK1 and sclerostin with BMD and arterial stiffness in predialysis CKD… CONTINUE READING
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