Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis

@inproceedings{BayJensen2013CirculatingPF,
  title={Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis},
  author={A C Bay-Jensen and Stephanie Wichuk and Inger Byrjalsen and Diana Julie Leeming and Nathalie Morency and Claus Christiansen and Morten Asser Karsdal and Walter P. Maksymowych},
  booktitle={PloS one},
  year={2013}
}
Inflammation driven connective tissue turnover is key in rheumatic diseases, such as ankylosing spondylitis (AS). Few biomarkers are available for measuring disease prognosis or the efficacy of interventions applied in these tissue-related conditions. Type II collagen is the primary structural protein of cartilage and type III collagen of connective tissues, and obvious targets for the collagenalytic, which increase during tissue inflammation. The objective of the study was to investigate the… CONTINUE READING

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