Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.

@article{Asztalos2010CirculatingNI,
  title={Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.},
  author={Bela F. Asztalos and Zahedi Mujawar and Matthew P. Morrow and Angela R Grant and Tatiana Pushkarsky and Christine A. Wanke and Richard P. Shannon and Matthias Geyer and Frank Kirchhoff and Dmitri D. Sviridov and Michael L. Fitzgerald and Michael I. Bukrinsky and Keith G Mansfield},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 4},
  pages={614-23}
}
Human immunodeficiency virus (HIV) infection and subsequent antiretroviral therapy have been associated with an increased incidence of dyslipidemia and cardiovascular disease and has been shown to suppress cholesterol efflux from virus-infected macrophages by inducing Nef-dependent down-regulation of adenosine triphosphate-binding cassette transporter A1 (ABCA1). Here, the simian immunodeficiency virus (SIV)-infected macaque model was used to examine the consequences and mechanisms involved… CONTINUE READING

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Highly Influenced

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