Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury

  title={Circulating Mitochondrial DAMPs Cause Inflammatory Responses to Injury},
  author={Qin Zhang and Mustafa Raoof and Yu Chen and Yuka Sumi and Tolga Sursal and Wolfgang G. Junger and Karim Brohi and Kiyoshi Itagaki and Carl J. Hauser},
Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous ‘damage’-associated molecular patterns (DAMPs) that activate innate immunity. Mitochondria are evolutionary endosymbionts that were derived from bacteria and so might bear bacterial molecular motifs. Here we show that injury… CONTINUE READING
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