Circulating Microparticles, Blood Cells, and Endothelium Induce Procoagulant Activity in Sepsis through Phosphatidylserine Exposure.

@article{Zhang2016CirculatingMB,
  title={Circulating Microparticles, Blood Cells, and Endothelium Induce Procoagulant Activity in Sepsis through Phosphatidylserine Exposure.},
  author={Yan Zhang and Huan Meng and Ruishuang Ma and Zhangxiu He and Xiaoming Wu and Muhua Cao and Zhipeng Yao and Lu Zhao and Tao Li and Ruijuan Deng and Zengxiang Dong and Ye Tian and Yayan Bi and Junjie Kou and Hemant S. Thatte and Jin Zhou and Jialan Shi},
  journal={Shock},
  year={2016},
  volume={45 3},
  pages={299-307}
}
Sepsis is invariably accompanied by altered coagulation cascade; however, the precise role of phosphatidylserine (PS) in inflammation-associated coagulopathy in sepsis has not been well elucidated. We explored the possibility of exposed PS on microparticles (MPs), blood cells, as well as on endothelium, and defined its role in procoagulant activity (PCA) in sepsis. PS-positive MPs and cells were detected by flow cytometry, while PCA was assessed with clotting time, purified coagulation complex… CONTINUE READING
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