Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?

@article{Timms2002CirculatingMV,
  title={Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?},
  author={Peter Mclean Timms and Nasima Mannan and Graham A. Hitman and Kate Noonan and Peter G. Mills and Denise Syndercombe-Court and Ebun Aganna and Christopher P Price and Barbara J. Boucher},
  journal={QJM : monthly journal of the Association of Physicians},
  year={2002},
  volume={95 12},
  pages={787-96}
}
BACKGROUND Vitamin-D deficiency and vitamin-D receptor genotype (VDR) are risk factors for several disorders with inflammatory components, including coronary heart disease (CHD) and diabetes, though the mechanisms involved are unclear. AIM To examine the hypothesis that vitamin D status modulates the matrix metalloproteinase (MMP) system in a population with a high prevalence of vitamin D deficiency, a situation affecting susceptibility to CHD and diabetes. DESIGN Prospective cross… CONTINUE READING

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