Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination

  title={Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination},
  author={Suzette J. Bielinski and James S. Pankow and Michael B. Miller and Paul N. Hopkins and John H. Eckfeldt and James Hixson and Y H Liu and Tom Register and Richard H. Myers and Donna K. Arnett},
  journal={Genes and Immunity},
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47… 
Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators.
It is concluded that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines and also 2 mechanisms for the release of reservoir chemokines with possible clinical implications.
Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and Its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis
The combination of the MCP-1 CC homozygous genotype and the homozygotic or heterozygote CCR2 V64I genotype is associated with a particularly high prevalence of carotid artery plaque, which is independently associated with plaque in African American from families with premature coronary artery disease.
Association of Monocyte Chemoattractant Protein‐1 (MCP‐1)‐2518A>G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta‐Analysis
The results suggested that MCP‐1 ‐2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians, and a recessive model to be appropriate.
The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations
The authors' community-based data support the relevance of clinical and genetic factors for explaining variation in inflammatory biomarker traits and propose two novel potential candidates (APCS, MPO).
Association of monocyte chemoattractant protein-1-2518A/G polymorphism and risk of coronary artery disease among the Chinese population: a meta-analysis.
The MCP-1-2518A/G polymorphism was not associated with the risk of CAD in Chinese population and the pooled odds ratio with its 95% confidence interval was estimated.
Association between MCP-1 A 2518 G polymorphism and coronary artery disease risk : evidence from 21 case-control studies
The meta-analysis suggests the MCP-1 A2518G polymorphism (AG + GG genotypes) is a risk factor for CAD, and evidence of heterogeneity was found among the investigated studies.
Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial
  • H. Park, H. Lee
  • Medicine, Biology
    Nutrition research and practice
  • 2017
In healthy Korean elderly, spirulina supplementation may influence different inflammatory markers by the MCP-1 genotype, and these results may be useful for customized dietary guidelines to improve immune function in Koreans.
Genome-Wide Linkage Analysis of Cardiovascular Disease Biomarkers in a Large, Multigenerational Family
This work has measured 21 cardiovascular-related biomarkers in an extended multigenerational pedigree, the CARRIAGE family (Carolinas Region Interaction of Aging, Genes, and Environment), and four showed noteworthy evidence for linkage in multipoint analysis.


CCL2 Polymorphisms Are Associated With Serum Monocyte Chemoattractant Protein-1 Levels and Myocardial Infarction in the Framingham Heart Study
Background—Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory. Methods and
Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese.
Although genetic variations in CCL2 may have some influence on MCP-1 production, their influence does not seem to contribute appreciably to atherosclerosis in Japanese, and the present results did not support the recently published findings from the Framingham Heart Study.
Val64Ile Polymorphism in the C-C Chemokine Receptor 2 Is Associated With Reduced Coronary Artery Calcification
This study provides genetic evidence linking CCR2 with coronary atherosclerosis in humans by quantitatively phenotyping first-degree relatives of persons with premature coronary artery disease and finding the extent of CAC was significantly lower in subjects with the C CR2-Ile64 variant than in subjects carrying 2 Val64 alleles.
Chemokines and Incident Coronary Heart Disease: Results From the MONICA/KORA Augsburg Case-Cohort Study, 1984–2002
Elevated systemic levels of the chemokines MCP-1, IL-8, and IP-10 precede CHD but do not represent independent risk factors, and the associations are less pronounced than previously shown for type 2 diabetes.
Association Between Plasma Levels of Monocyte Chemoattractant Protein-1 and Long-Term Clinical Outcomes in Patients With Acute Coronary Syndromes
In a large cohort of patients with acute coronary syndromes, an elevated baseline level of MCP-1 was associated both with traditional risk factors for atherosclerosis as well as an increased risk for death or myocardial infarction, independent of baseline variables.
Differential Expression of Chemokines, Risk of Stable Coronary Heart Disease, and Correlation with Established Cardiovascular Risk Markers
There may be no universal upregulation of chemokines in CHD-associated inflammation but different up regulation of IP-10 and IL-8 versus downregulation of RANTES; there was no clear disease association for MCP-1, MIP-1&agr;, or eotaxin.
Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age
The CCR2 genotype seems to predispose patients for myocardial infarction before the age of 65 years and is associated with higher mortality in the general population, which must be investigated in further studies.