Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination

@article{Bielinski2007CirculatingML,
  title={Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination},
  author={Suzette J. Bielinski and James S. Pankow and Michael B. Miller and Paul N. Hopkins and John H. Eckfeldt and James Hixson and Y H Liu and Tom Register and Richard H. Myers and Donna K. Arnett},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={684-690}
}
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47… 
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The results suggested that MCP‐1 ‐2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians, and a recessive model to be appropriate.

The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations

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The authors' community-based data support the relevance of clinical and genetic factors for explaining variation in inflammatory biomarker traits and propose two novel potential candidates (APCS, MPO).

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TLDR
A meta-analysis indicates that MCP-1-2518A>G polymorphism may be a risk factor for myocardial infarction, especially among Asian populations.

Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor.

TLDR
The results of these analyses indicate that, if maternal CCL-2 genotype is related to the risk of spina bifida, this relationship is likely to be more complex than initially hypothesized, perhaps depending upon folate intake, MTHFR 677C>T genotype, the distribution of folate derivatives, and immune/inflammatory activity.

Association of monocyte chemoattractant protein-1-2518A/G polymorphism and risk of coronary artery disease among the Chinese population: a meta-analysis.

TLDR
The MCP-1-2518A/G polymorphism was not associated with the risk of CAD in Chinese population and the pooled odds ratio with its 95% confidence interval was estimated.

Original Article Association of monocyte chemoattractant protein-1-2518A/G polymorphism and risk of coronary artery disease among the Chinese population: a meta-analysis

TLDR
The MCP-1-2518A/G polymorphism was not found to be significantly associated with CAD risk in Chinese population, and no associations were found in subgroup analysis based on source of control and endpoint.

Quantile-specific heritability of monocyte chemoattractant protein-1, and relevance to rs1024611-disease interactions.

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