Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination

@article{Bielinski2007CirculatingML,
  title={Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination},
  author={Suzette J. Bielinski and James S. Pankow and Michael B. Miller and Paul N. Hopkins and John H. Eckfeldt and James Hixson and Y H Liu and Tom Register and Richard H. Myers and Donna K. Arnett},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={684-690}
}
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47… 
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The results suggested that MCP‐1 ‐2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians, and a recessive model to be appropriate.
The Relation of Genetic and Environmental Factors to Systemic Inflammatory Biomarker Concentrations
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The authors' community-based data support the relevance of clinical and genetic factors for explaining variation in inflammatory biomarker traits and propose two novel potential candidates (APCS, MPO).
Association of monocyte chemoattractant protein-1-2518A/G polymorphism and risk of coronary artery disease among the Chinese population: a meta-analysis.
TLDR
The MCP-1-2518A/G polymorphism was not associated with the risk of CAD in Chinese population and the pooled odds ratio with its 95% confidence interval was estimated.
Association between MCP-1 A 2518 G polymorphism and coronary artery disease risk : evidence from 21 case-control studies
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The meta-analysis suggests the MCP-1 A2518G polymorphism (AG + GG genotypes) is a risk factor for CAD, and evidence of heterogeneity was found among the investigated studies.
Monocyte chemoattractant protein-1 polymorphism interaction with spirulina immunomodulatory effects in healthy Korean elderly: A 16 week, double-blind randomized clinical trial
  • H. Park, H. Lee
  • Medicine, Biology
    Nutrition research and practice
  • 2017
TLDR
In healthy Korean elderly, spirulina supplementation may influence different inflammatory markers by the MCP-1 genotype, and these results may be useful for customized dietary guidelines to improve immune function in Koreans.
Genome-Wide Linkage Analysis of Cardiovascular Disease Biomarkers in a Large, Multigenerational Family
TLDR
This work has measured 21 cardiovascular-related biomarkers in an extended multigenerational pedigree, the CARRIAGE family (Carolinas Region Interaction of Aging, Genes, and Environment), and four showed noteworthy evidence for linkage in multipoint analysis.
Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C.
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