Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination

@article{Bielinski2007CirculatingML,
  title={Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination},
  author={Suzette J. Bielinski and James S. Pankow and Michael B. Miller and Paul N. Hopkins and John H. Eckfeldt and James Hixson and Y H Liu and Tom Register and Richard H. Myers and Donna K. Arnett},
  journal={Genes and Immunity},
  year={2007},
  volume={8},
  pages={684-690}
}
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47… 
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  • 2017
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