Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination
@article{Bielinski2007CirculatingML, title={Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI Family Heart Study follow-up examination}, author={Suzette J. Bielinski and James S. Pankow and Michael B. Miller and Paul N. Hopkins and John H. Eckfeldt and James Hixson and Y H Liu and Tom Register and Richard H. Myers and Donna K. Arnett}, journal={Genes and Immunity}, year={2007}, volume={8}, pages={684-690} }
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47…
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