Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts.

  title={Circulating Leptin and Risk of Pancreatic Cancer: A Pooled Analysis From 3 Cohorts.},
  author={Rachael Z. Stolzenberg-Solomon and Christina C. Newton and Debra T. Silverman and Michael J Pollak and Leticia M. Nogueira and Stephanie J Weinstein and Demetrius Albanes and Satu M{\"a}nnist{\"o} and Eric J Jacobs},
  journal={American journal of epidemiology},
  volume={182 3},
Adiposity is associated with pancreatic cancer; however, the underlying mechanism(s) is uncertain. Leptin is an adipokine involved in metabolic regulation, and obese individuals have higher concentrations. We conducted a pooled, nested case-control study of cohort participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and the Cancer Prevention Study II Nutrition Cohort to investigate whether… CONTINUE READING


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