Circulating IgG antibody to protamine in patients treated with protamine-insulins

@article{Kurtz1983CirculatingIA,
  title={Circulating IgG antibody to protamine in patients treated with protamine-insulins},
  author={Alfred B. Kurtz and Robert S. Gray and S. Markanday and J. D. N. Nabarro},
  journal={Diabetologia},
  year={1983},
  volume={25},
  pages={322-324}
}
Sera from patients treated with different types of protamine-insulin were assayed for IgG antibody to protamine. A high prevalence of circulating antibody was found in patients treated with either bovine isophane insulin (26 out of 28 patients; 26 of whom also had antibodies to insulin), or bovine protamine zinc insulin (27 out of 30 patients; all 30 had antibodies to insulin). In sera from 24 patients treated with highly purified porcine isophane insulin, protamine antibody was detected in… CONTINUE READING

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