Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.

@article{Schultz2016CirculatingHI,
  title={Circulating HIV-Specific Interleukin-21(+)CD4(+) T Cells Represent Peripheral Tfh Cells with Antigen-Dependent Helper Functions.},
  author={Bruce T Schultz and Jeffrey E. Teigler and Franco Pissani and Alexander F Oster and Gregory Kranias and Galit Alter and Mary A. Marovich and Michael A Eller and Ulf Dittmer and Merlin L. Robb and Jerome H. Kim and Nelson L Michael and Diane L Bolton and Hendrik Streeck},
  journal={Immunity},
  year={2016},
  volume={44 1},
  pages={167-178}
}
A central effort in HIV vaccine development is to generate protective broadly neutralizing antibodies, a process dependent on T follicular helper (Tfh) cells. The feasibility of using peripheral blood counterparts of lymph node Tfh cells to assess the immune response and the influence of viral and vaccine antigens on their helper functions remain obscure. We assessed circulating HIV-specific IL-21(+)CD4(+) T cells and showed transcriptional and phenotypic similarities to lymphoid Tfh cells, and… CONTINUE READING
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International AIDS Vaccine Initiative Protocol C

  • M. Locci, C. Havenar-Daughton, +7 authors A Sette
  • Principal Investigators
  • 2013
Highly Influential
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