Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.

  title={Circulating FGF21 proteolytic processing mediated by fibroblast activation protein.},
  author={Eugene Yuejun Zhen and Zhaoyan Y Jin and Bradley L. Ackermann and Melissa K. Thomas and Jesus Aguirre Guti{\'e}rrez},
  journal={The Biochemical journal},
  volume={473 5},
Fibroblast growth factor 21 (FGF21), a hormone implicated in the regulation of glucose homoeostasis, insulin sensitivity, lipid metabolism and body weight, is considered to be a promising therapeutic target for the treatment of metabolic disorders. Despite observations that FGF21 is rapidly proteolysed in circulation rending it potentially inactive, little is known regarding mechanisms by which FGF21 protein levels are regulated. We systematically investigated human FGF21 protein processing… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

FGF 21based pharmacotherapy – potential utility for metabolic disorders

  • A. C. Adams, C. A. Halstead, B. C. Hansen, A. R. Irizarry, J. A. Martin
  • Trends Endocrinol . Metab .
  • 2014

Similar Papers

Loading similar papers…