Circulating Estradiol and Osteoprotegerin as Determinants of Bone Turnover and Bone Density in Postmenopausal Women

@article{Rogers2002CirculatingEA,
  title={Circulating Estradiol and Osteoprotegerin as Determinants of Bone Turnover and Bone Density in Postmenopausal Women},
  author={Angela Rogers and Gamal Saleh and Rosemary A Hannon and David Greenfield and Richard Eastell},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 10},
  pages={4470-5}
}
Osteoprotegerin (OPG) is a recently identified cytokine that acts as a decoy receptor for the receptor activator of NF kappa B ligand. OPG has been shown to be an important inhibitor of osteoclast differentiation and activation in rodent models. Estrogen is known to suppress bone resorption, and the action of estrogen on bone may be mediated by OPG. The relationship between endogenous estrogen and circulating OPG levels and bone status in human populations is unclear. Thus, the aim of this… CONTINUE READING

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