Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care.

@article{Messaoudi2016CirculatingDA,
  title={Circulating DNA as a Strong Multimarker Prognostic Tool for Metastatic Colorectal Cancer Patient Management Care.},
  author={Safia El Messaoudi and Florent Mouliere and Stanislas du Manoir and C. Bascoul-Mollevi and Brigitte Gillet and Michelle Nouaille and Catherine Fiess and Evelyne Crapez and Frederic F Bibeau and Charles Theillet and Thibault Mazard and Denis Pezet and Muriel Mathonnet and M arc Ychou and Alain R. Thierry},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 12},
  pages={
          3067-77
        }
}
PURPOSE Circulating cell-free DNA (ccfDNA) is a valuable source of tumor material obtained from a simple blood sampling that enables noninvasive analysis of the tumor genome. Our goal was to carry out a multiparametric analysis of ccfDNA and evaluate its prognostic value by investigating the overall survival (OS) of 97 metastatic colorectal cancer patients (mCRC). EXPERIMENTAL DESIGN Qualitative parameters (determination of the main KRAS exon2 and BRAF V600E mutations) and quantitative… CONTINUE READING
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