Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer.

@article{Thierry2017CirculatingDD,
  title={Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer.},
  author={Alain R. Thierry and Brice Pastor and Zhi-qin Jiang and Anastasia D. Katsiampoura and Christine M Parseghian and Jonathan M. Loree and Michael James Overman and Cynthia S{\'a}nchez and Safia El Messaoudi and Marc Ychou and Scott Kopetz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 16},
  pages={
          4578-4591
        }
}
Purpose: Liquid biopsies allow the tracking of clonal dynamics and detection of mutations during treatment.Experimental Design: We evaluated under blinded conditions the ability of cell-free DNA (cfDNA) to detect RAS/BRAF mutations in the plasma of 42 metastatic colorectal cancer patients treated on a phase Ib/II trial of FOLFOX and dasatinib, with or without cetuximab.Results: Prior to treatment, sequencing of archival tissue detected mutations in 25 of 42 patients (60%), while the cfDNA assay… CONTINUE READING