Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review

  title={Circulating Cell-Free DNA and Colorectal Cancer: A Systematic Review},
  author={V. Vymetalkova and Klara Cervena and Linda Bartu and P. Vodicka},
  journal={International Journal of Molecular Sciences},
  • V. Vymetalkova, Klara Cervena, +1 author P. Vodicka
  • Published 2018
  • Medicine, Biology
  • International Journal of Molecular Sciences
  • There is a strong demand for the identification of new biomarkers in colorectal cancer (CRC) diagnosis. Among all liquid biopsy analysts, cell-free circulating DNA (cfDNA) is probably the most promising tool with respect to the identification of minimal residual diseases, assessment of treatment response and prognosis, and identification of resistance mechanisms. Circulating cell-free tumor DNA (ctDNA) maintains the same genomic signatures that are present in the matching tumor tissue allowing… CONTINUE READING
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