Circulating CXCR5+CD4+ T cells assist in the survival and growth of primary diffuse large B cell lymphoma cells through interleukin 10 pathway.

@article{Cha2017CirculatingCT,
  title={Circulating CXCR5+CD4+ T cells assist in the survival and growth of primary diffuse large B cell lymphoma cells through interleukin 10 pathway.},
  author={Zhanshan Cha and Guangfang Qian and Yan Zang and Haihui Gu and Yanyan Huang and Lishuang Zhu and Jinqi Li and Yang Liu and Xiaohua Tu and Haihan Song and Baohua Qian},
  journal={Experimental cell research},
  year={2017},
  volume={350 1},
  pages={154-160}
}
Diffuse large B cell lymphoma (DLBCL) is a common and aggressive cancer caused by the malignant transformation of B cells. Although it has been established that the follicular helper T (Tfh) cells play a central role in B cell development, little information is available on their involvement in DLBCL pathogenesis. We studied the role of the peripheral Tfh equivalent, the CXCR5+ CD4+ T cells, in DLBCL. Data showed that compared to CXCR5- CD4+ T cells, CXCR5+ CD4+ T cells were significantly more… CONTINUE READING