Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.

@article{Song2018CirculatingCS,
  title={Circulating CD8+CD28- suppressor T cells tied to poorer prognosis among metastatic breast cancer patients receiving adoptive T-cell therapy: A cohort study.},
  author={Qingkun Song and Jun Ren and Xinna Zhou and Xiaoli Wang and Guohong Song and Amy C. Hobeika and Yanhua Yuan and Herbert Kim Lyerly},
  journal={Cytotherapy},
  year={2018},
  volume={20 1},
  pages={
          126-133
        }
}
BACKGROUND AIMS This study aimed to determine the prognostic value of circulating CD8+CD28- T lymphocytes among breast cancer patients treated with adoptive T-lymphocyte immunotherapy after chemotherapy. METHODS Two hundred and thirty-two breast cancer patients underwent adoptive T-cell immunotherapy. Circulating CD8+CD28- proportion was measured by flow cytometry. Median proportion of CD8+CD28- was 24.2% and set as the categorical cutoff value for further analysis. The median survival was… CONTINUE READING
BETA