Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients.

@article{Suades2014CirculatingCL,
  title={Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients.},
  author={Rosa Suades and Teresa Padro and R Gonz{\'a}lez Alonso and Jose L{\'o}pez-Miranda and Pedro L Mata and L Badimon},
  journal={Thrombosis and haemostasis},
  year={2014},
  volume={111 1},
  pages={111-21}
}
Circulating microparticles (cMPs) seem to play important roles in vascular function. Beyond markers of activated cells, cMPs may have potential paracrine functions and influence atherosclerosis. Here, our objective was to characterise a) the abundance and phenotype of cMPs in stable statin-treated heterozygous familial hypercholesterolaemia (FH) patients exposed to life-long hypercholesterolaemia and b) the principal phenotype associated to lipid-rich atherosclerotic plaques in hFH-patients… CONTINUE READING