Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.

@article{Hartmann2009CirculatingBC,
  title={Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow.},
  author={Tanja N Hartmann and Valentin Grabovsky and Wei Wang and Petra Desch and Gabriele Rubenzer and Stefan Wollner and Inbal Binsky and Alexandra Vallon-Eberhard and Anita Sapoznikov and Meike Burger and Idit Shachar and Michal Haran and Marek J Honczarenko and Richard Greil and Ronen Alon},
  journal={Cancer research},
  year={2009},
  volume={69 7},
  pages={3121-30}
}
Homing to secondary lymphoid organs and bone marrow (BM) is a central aspect of leukemic pathophysiology. We investigated the roles of the two major lymphocyte integrins LFA-1 and VLA-4 on B-cell chronic lymphocytic leukemia (CLL) cells in these processes. We found that the majority of CLL cells expressed significantly reduced LFA-1 due to low beta2 integrin transcripts. VLA-4 expression was heterogeneous but underwent rapid activation by the BM chemokine CXCL12. CLL cells failed to… CONTINUE READING

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