Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis.

@article{Dieker2016CirculatingAM,
  title={Circulating Apoptotic Microparticles in Systemic Lupus Erythematosus Patients Drive the Activation of Dendritic Cell Subsets and Prime Neutrophils for NETosis.},
  author={J{\"u}rgen W C Dieker and Jurjen Tel and Elmar Pieterse and Astrid J F Thielen and Nils Rother and M arinka A. H. Bakker and Jaap Fransen and Henry B. P. M. Dijkman and Jo H. M. Berden and Jolanda M. de Vries and Luuk B Hilbrands and Johan van der Vlag},
  journal={Arthritis & rheumatology},
  year={2016},
  volume={68 2},
  pages={462-72}
}
OBJECTIVE Circulating chromatin-containing apoptotic material and/or neutrophil extracellular traps (NETs) have been proposed to be an important driving force for the antichromatin autoimmune response in patients with systemic lupus erythematosus (SLE). The aim of this study was to determine the exact nature of microparticles in the circulation of SLE patients and to assess the effects of the microparticles on the immune system. METHODS We analyzed microparticles isolated from the plasma of… CONTINUE READING